Why how on beating the virus is so important

 

Scientists and governments are making over hours to bring the SARS-CoV-2 outbreak under control. Still, how on beating SARS-CoV-2 is essential.

Medicine is a highly divided discipline. Also, under less stressed circumstances, there is not much of an eye for systemic effects beyond the scope of research. When a test says it works, it works. And if in the limited research timeframe nothing bad of statistical significance happens, a treatment is considered safe.

What’s wrong with this way of thinking when it comes to Covid-19? 

SARS-CoV-2 enters the cell by binding to ACE2 (angiotensin converting enzyme 2), so targeting ACE2 to prevent such binding seems an obvious strategy to combat infection. However, ACE2 plays an important role in maintaining vital biological processes. A deficiency of this enzyme may have dire consequences and correlates to Alzheimer, kidney failure, cancer and dementia.

Second, experts believe that the virus we are dealing with, or maybe its very close relatives, will become seasonal. The only reason why SARS-CoV-2 is potentially lethal is that it is still new to us. So there is no adaptive immune response yet, and you might dye because of an overactive non-specific native immune response. Just like the Indians died on our common cold after the Spanish discovered America. 

It means a treatment that works, but blocks this critical process, should be reconsidered. To prevent reinfection, and weapon our body’s for the future outbreaks, the development of the adaptive immune response is vital. 

Our Call for action is about:

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– Let the insights on the proposed disease mechanism and the advanced role ACE2 set the conditions for future research.

– Let it be a reference to audit trials, and drug candidates.

– Reconsider current treatments, or the way how to use them.

– Start testing AT1R antagonists against Covid-19, it matches all criteria, we really need to know if it works praxis too.

Are you a researcher or clinician? Endorse our call for action..